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Assess renal function more frequently in elderly patients [see Use in Specific Populations (8.5)]

To confirm that the observed effects were mediated through direct GLP-1R activation, or indeed, that they are not secondary autocrine effects of insulin, we performed 2-NBDG uptake experiments in the presence of the GLP1R antagonist Exendin (939) and the potassium channel opener, diazoxide

Titration of GLP-1RA based on the individuals response in weight and glycemic control is recommended